Kisspeptin-10 (10mg)

Kisspeptin-10 and Reproductive Modulation

Derived from the KISS1 gene, Kisspeptin-10, a naturally occurring peptide, undergoes cleavage from its original 145 amino acid form to a smaller peptide consisting of 54 amino acids. While initially recognized for its potential role as a metastasis suppressor in melanomas and breast carcinomas, Kisspeptin-10’s evolving expression profile suggests a distinct functionality on the hypothalamus and pituitary gland. This alteration in expression raises the possibility of its involvement in reproductive processes, with ongoing research exploring its potential impact on the intricate regulatory mechanisms of the reproductive system.

Several investigations in the mid-2000s indicated a potential connection between Kisspeptin-10 and hypogonadotropic hypogonadism, highlighting its role as a ligand for the G-protein coupled receptor 54 (GPR54). Ongoing research endeavors aim to delve deeper into this aspect of the Kisspeptin-10 peptide. Hypogonadism, a systemic disorder characterized by reduced or absent sex hormone production, manifests in various forms. Hypogonadotropic hypogonadism specifically arises from the under-functioning of the pituitary gland or hypothalamus. The hypothalamus stimulates the pituitary gland through gonadotropin-releasing hormone (GnRH), leading to the release of follicle-stimulating hormone (FSH) and luteinizing hormone (LH), crucial regulators of reproductive function. Insufficient levels of these hormones, including GnRH, FSH, and LH, constitute key factors in hypogonadotropic hypogonadism.

Kisspeptin-10: GPR54 Receptor Interaction

GPR54, also identified as the KISS1 receptor (KISS1R), is postulated by researchers to play a pivotal role as a GnRH receptor. Investigations suggest that Kisspeptin-10 may exert its effects by potentially binding to GPR54 receptors, activating the reproductive axis through the stimulation of GnRH and gonadotropin neurons. Comprising 54 amino acids, Kisspeptin-10 is a product of the KISS1 gene. Researchers have identified smaller peptide fragments like Kisspeptin 10, 13, and 14, all demonstrating some biological activity towards GPR54. These smaller peptides are thought to bind with low affinity to GPR54 receptors, potentially inducing calcium mobilization, arachidonic acid release, and extracellular protein kinase phosphorylation. These events may contribute to the depolarization of Kisspeptin-10 neurons, subsequently influencing GnRH neurons and modulating gonadotropin release to a certain extent. Various research studies on Kisspeptin-10 have explored its potential across a spectrum of functions, offering diverse hypotheses on the peptide’s mechanisms of action.

.Might have the capacity to trigger the release of GnRH
.Possibly induces the release of endogenous gonadotropins in animal models with reduced fertility
.Elevated peptide concentrations may lead to the desensitization and suppression of the hypothalamus, pituitary gland, and gonadal axis

Exploration and Clinical Investigations

Kisspeptin-10 and Neuroendocrine Regulation

In a comprehensive analysis conducted in 2018,(11) various scientific publications from 2000 to 2017 were scrutinized to explore the potential role of Kisspeptin-10 in neuroendocrine regulation. The literature review revealed compelling evidence suggesting that Kisspeptin-10, along with its associated KISS1 gene and GPR54 receptors, may exert influence on the intricate network of neuroendocrine signaling. Numerous studies pointed towards the modulation of gonadotropin hormones and hinted at the involvement of Kisspeptin-10 in the regulation of the neuroendocrine axis. Additionally, investigations on animal models resembling characteristics of reproductive disorders, such as hypogonadotropic hypogonadism and polycystic ovarian syndrome, indicated disruptions in the KISS1 and GPR54 system, further emphasizing the potential neuroendocrine regulatory role of Kisspeptin-10.

Kisspeptin-10 and Metabolic Influence

In a recent clinical investigation conducted in 2020,(14) the focus was shifted towards exploring the potential metabolic impact of Kisspeptin-10. The study aimed to assess whether Kisspeptin-10 could have implications for metabolic processes beyond its known reproductive role. A group of 20 participants with varying metabolic profiles were enrolled, and they were administered either Kisspeptin-10 or a placebo. The study monitored key metabolic parameters, including glucose metabolism, insulin sensitivity, and lipid profiles. The preliminary findings suggested that Kisspeptin-10 might exhibit some influence on metabolic markers, hinting at a broader physiological role beyond its established involvement in the reproductive system. Ongoing research endeavors aim to delve deeper into the intricate connections between Kisspeptin-10 and metabolic regulation.

Kisspeptin-10 and Cognitive Function

In a recent cognitive study conducted in 2021,(15) the objective was to explore the impact of Kisspeptin-10 on cognitive functions. The study involved 30 participants, both male and female, who were administered either Kisspeptin-10 or a placebo. Cognitive assessments were conducted using standardized tests to evaluate memory, attention, and executive functions. The preliminary findings indicated potential cognitive modulation by Kisspeptin-10, with subjects showing improvements in specific cognitive domains. This intriguing avenue of research opens new possibilities for understanding the peptide’s role in cognitive processes and its implications for brain function. Ongoing investigations aim to unravel the intricate connections between Kisspeptin-10 and cognitive function.

Kisspeptin-10 and Cardiovascular Impact

In a recent clinical investigation conducted in 2022,(16) the primary focus was to examine the potential cardiovascular impact of Kisspeptin-10. Test subjects with cardiovascular risk factors were administered Kisspeptin-10, and various cardiovascular parameters were assessed. Preliminary findings suggested potential vasodilatory effects, as evidenced by improved blood flow dynamics in certain vascular beds. Additionally, the study explored the influence of Kisspeptin-10 on markers of vascular inflammation and oxidative stress. Ongoing research endeavors delve deeper into understanding the intricate interplay between Kisspeptin-10 and cardiovascular health, providing valuable insights into its multifaceted physiological roles.

Kisspeptin-10 and Sleep Regulation

Exploring the potential influence of Kisspeptin-10 on sleep regulation, a recent study(12) sought to investigate its impact on sleep patterns and quality. Test subjects, comprising both male and female individuals, were administered Kisspeptin-10 prior to bedtime, and their sleep parameters were closely monitored through polysomnography. The findings indicated alterations in sleep architecture, with a noticeable increase in the duration of REM (rapid eye movement) sleep. Interestingly, there was also a reduction in the occurrence of wakefulness during the sleep cycle. These outcomes hint at the intricate involvement of Kisspeptin-10 in the regulation of sleep stages, shedding light on its potential as a modulator of sleep-related physiological processes. Ongoing research endeavors aim to unravel the detailed mechanisms underlying Kisspeptin-10’s impact on sleep regulation.

Kisspeptin-10 in Neurological Disorders

Exploring the potential implications of Kisspeptin-10 in neurological disorders, a recent investigation(13) delved into its role in mouse models displaying symptoms akin to neurodegenerative conditions. The study aimed to discern whether Kisspeptin-10 has any impact on cognitive function and neuronal health. Mice with induced neurological dysfunction were administered Kisspeptin-10, and subsequent assessments revealed improved cognitive performance compared to the untreated group. Furthermore, there were indications of enhanced neuroprotection, suggesting a potential neurotherapeutic avenue. This research highlights the multifaceted roles of Kisspeptin-10, extending beyond its established connections with reproductive functions, into the intricate realm of neurological well-being. Ongoing studies seek to elucidate the specific mechanisms through which Kisspeptin-10 may exert its neuroprotective effects.

Kisspeptin-10 peptide is exclusively accessible for scientific research and laboratory applications. Prospective users are encouraged to thoroughly review and comply with the stipulated Terms and Conditions before initiating the ordering process.