Epitalon (25mg)

Epitalon Peptide and Neurological Impact

Exploration into Epitalon, a tetrapeptide with alternative names such as AEDG peptide, Epithalon, or Epithalone, has unveiled potential regulatory effects on neurological functions. Scientific inquiries suggest that Epitalon may influence the brain, the pineal gland, and the retina of the eye. The ongoing research delves into diverse hypotheses, including its potential role in enhancing sleep by stimulating the pineal gland to release more melatonin. Additionally, studies propose that the peptide might stimulate telomerase generation, showcase robust antioxidant properties, and possibly contribute to extending the functional integrity of the retina.

Leveraging contemporary technological advancements and ongoing strides in scientific research, methodologies have emerged to craft intricate peptide formulations from various tissue extracts. Among these peptides found in tissues is ‘Epithalamin,’ a natural compound produced within the pineal gland. Epithalamin is purported to play a role in boosting melatonin production, enhancing immune and anti-carcinogenic functions in rodents, and rejuvenating reproductive capabilities in aging rodents. Clinical studies have mirrored these actions of the endogenous peptide. Building upon these breakthroughs, a synthesized counterpart akin to Epithalamin has been developed and named ‘Epitalon.’ This synthetic peptide draws inspiration from its naturally occurring counterpart found in both the pineal gland and the eye retina.

Overview

Epitalon, alternatively known as Epithalon or Epithalone, represents a synthetic tetrapeptide recognized as the AEDG peptide, comprising the amino acids Ala-Glu-Asp-Gly.(2) This peptide is proposed to function akin to Epithalamin, operating through diverse pathways. The potential mechanisms and additional investigations into its actions are expounded upon in the subsequent discussions.

Exploration and Clinical Investigations

Epitalon Peptide and Cellular Renewal

Studies(2) propose that the peptide engages with histones – HI/6 and HI/3 – located at distinct sites in tissues, influencing DNA interactions. This suggested interaction with histones may contribute to an increase in neurogenic differentiation of gene transcription, involving markers like Nestin, Beta Tubulin III, and Doublecortin, by 1.6 to 1.8 times the normal rate. This potential impact on neuronal differentiation and protein synthesis in retinal and ligament stem cells may facilitate enhanced cellular functionality.

Epitalon Peptide and Cellular Rejuvenation

To unravel the potential anti-aging effects of different synthetic peptides, extensive research has been undertaken to explore their impact on cellular proliferation, regeneration, apoptosis, and matrix remodeling.(5) Findings suggest that Epitalon may impede the synthesis of MM-9, an enzyme that tends to elevate with age, while simultaneously enhancing the processes of cellular proliferation and regeneration, which typically decline with advancing age.

Epithalon Peptide and Rejuvenation Potential in Fetal Cells

To investigate the impact of the peptide on fetal fibroblastic cells, a study(6) was conducted focusing on the proliferative capacity of pulmonary fibroblasts isolated from a 24-week-old fetus. These fibroblasts exhibited a decline in proliferative function by the 34th passage, accompanied by a significant reduction in telomere size compared to the 10th passage. Introducing Epitalon to these aging cells appeared to stimulate telomere development, leading to an increase in size and restoration to their normal dimensions. This elongation of telomeres resulted in 10 additional cell divisions compared to the control cells, suggesting that Epitalon surpassed the Hayflick limit and extended the normal cell cycle in these cells.⁽⁶⁾

Epitalon Peptide and Cellular Rejuvenation in Aging Subjects

A clinical study⁽⁷⁾ focused on lymphocytic cells isolated from individuals aged between 76 and 80 years aimed to investigate Epitalon’s impact on ribosomal cell activity and its effects on heterochromatin denaturation and polymorphism. The study revealed that upon administering Epitalon to the cell culture, the peptide seemed to activate ribosomal genes and induce decondensation of heterochromatin. Consequently, it appeared to facilitate the release of genes that were suppressed due to the aging of chromosomal regions. This study suggests that Epitalon may hold the potential to modify chromosomal regions in aging cells, activate chromatin, and restore cellular activities that might be suppressed or delayed in geriatric individuals.

Epitalon Peptide and Genomic Stability

In a 2011 study,sup>(8) involving three distinct mice models, Epitalon’s impact on chromosomal aberrations was examined. The models included SAMP-1 female mice with accelerated aging, along with wild rats SAMR-1 and SHR (both female mice). Following the administration of Epitalon, the occurrence of chromosomal aberrations in the bone marrow of SAMP-1 mice with accelerated aging was observed to be nearly twice as high as in the other two models. When the peptide was introduced at the age of 2 months in the mice, it seemingly reduced chromosomal aberrations in all three models, with the most significant effect observed in SAMP-1 mice with accelerated aging. The concurrent administration of melatonin at night, given with water, did not reportedly impact the peptide’s action. This study suggests that Epitalon may harbor anti-mutagenic properties, potentially contributing to genomic stability.

Epithalon Peptide and Antitumor Effects

In a study conducted on one-year-old female (C3H/He) mice with tumors affecting reproductive organs, including mammary glands and ovaries, various variants of invasive ductal carcinogenic cells were observed in mammary gland tumors, while granulosa cell tumors were found in the ovaries.(9) After being maintained in standard conditions for six months, the mice were divided into two groups: the control group and the experimental group, where Epitalon was administered five times a week. Upon completion of the study, three out of nine mice in the control group exhibited metastasis and an increase in the number of tumor cells. In contrast, the mice treated with the peptide showed a decrease in the number of tumor cells. The delivery of Epitalon appeared to inhibit the metastatic process, impeding the tumor cell cycle and growth. The researchers suggest the potential antitumor effects of the peptide.

Epitalon Peptide and Thymus Morphology in Hypophysectomized Birds

In a study involving hypophysectomized birds, both young and old, researchers aimed to investigate the impact of Epitalon peptide on the morphology of the thymus gland.(10) Hypophysectomized birds undergo surgical removal of the pituitary gland. Following the administration of the peptide, it was observed that the morphology of the thymus gland was restored in all birds, irrespective of their age. The most notable improvements were documented in birds, particularly chickens, subjected to neonatal hypophysectomy before the introduction of the peptide.

Epitalon Peptide and Circadian Rhythms

In a study involving aging monkeys and clinical subjects, the focus was on investigating the impact of Epitalon on circadian rhythms, specifically melatonin levels.(11) As individuals age, melatonin levels tend to decline, leading to challenges in sleep, particularly during the night. This decline is often associated with the deterioration of pineal gland function and a reduction in hormone circadian rhythm amplitude. The introduction of Epitalon appeared to mimic the natural secretion of the pineal gland, resulting in an increase in melatonin levels in the body, particularly during the night. This effect could potentially contribute to improved sleep patterns in elderly individuals.

Epitalon Peptide and Cognitive Function

In a clinical study examining geriatric subjects, the impact of Epitalon on cognitive function was assessed.(12) The findings suggested that the introduction of Epitalon may enhance bioelectric and functional activities in the brain’s cognitive center, potentially contributing to the preservation of cognitive function. The observed positive clinical outcomes in 90% of the subjects presented with the peptide raise the possibility of Epitalon playing a role in reversing age-related cognitive decline in the elderly.

Epitalon Peptide and Long-Term Health

In a comprehensive study spanning 6 to 8 years and involving 266 elderly subjects aged over 60 years, the geroprotective properties of Epitalon were investigated alongside the peptide-bioregulator Thymalin.(13) The outcomes indicated that both peptides exhibited the potential to restore fundamental bodily functions in the elderly, showcasing improvements in cardiovascular, endocrine, immune, and nervous system functions, as well as normalized metabolic and hemostatic activities. Notably, the peptide-treated groups demonstrated a significant 2-fold reduction in prevalent geriatric disorders, including acute respiratory issues, heart diseases, and bone disorders. Furthermore, the mortality rate in subjects receiving the peptides witnessed substantial decreases, with a 2-fold reduction in the Thymalin group, a 1.8-fold reduction in the Epitalon group, and a notable 2.5-fold reduction in subjects presented with both peptides.
Epitalon Peptide Access Information: Exclusively intended for research and laboratory use, Epitalon peptide is accessible under specific terms and conditions. Prior to placing an order, kindly review and adhere to the stipulated terms and conditions for procurement.